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SEPN

SEPN

Septerna, Inc.
$40.76
+3.58% Oct 21 close
Healthcare Compare
1M3M6M1Y2Y
-19%+14%+48%+81%+115%Oct 2025Oct 2026Apr 2026
SEPNSPY
1W
+12.2%
1M
+5.8%
3M
+19.2%
6M
+57.6%
YTD
+46.2%
1Y
+91.3%

Live chart

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What they do

Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism.

Healthcare · Biotechnology

For information only · Important disclosures

Grades vs sector

No sector grades for SEPN yet. Grades rank S&P 1500 stocks within their sector and refresh after each daily data run, so a stock outside that index or newly covered has none.

Our models

Held by 1 of 5 live models: New Highs Growth.

New Highs Growth
4.0% of the book
 HeldQuality Growth
Outside this model's universe or screens
 Momentum Top 15
Outside this model's universe or screens
 Momentum Blend
Not in the current book
 Coteau Long Book
Not in the current book
Why it's in the New Highs Growth

Qualified on Pharma, -19% from 52-week high, revenue +22376% y/y, 12-1 momentum +110%.

What would knock it out: Drops out if it falls outside the top 25 at the next rebalance (Oct 30). In the latest preview (2026-10-20) it is outside the top 25.

News

More news
No recent headlines.

Key stats

Market value$1.9B
P/E (next 12 months, estimated)-21.3
52-week range$17.55 – $51.10
Revenue growth (latest quarter vs a year ago)+22375.6%
Dividend yieldNo dividend
Average analyst price target$54.22 (+33%)
Valuation and fundamentals

Valuation & fundamentals

Bottom line
Looks undervalued
Model read-out from the numbers below, not advice. Score +3 (DCF counts double).
▲DCF (base case)above the price by 283%
•Piotroski F-score5/9
▲Altman Z6.5 (safe)
▲Analyst target+33% (9 analysts)

Discounted cash flow

Bear
$73
+78%
growth 18% · disc. 10.2% · term. 2.0%
Base
$156
+283%
growth 30% · disc. 9.2% · term. 2.5%
Bull
$291
+614%
growth 38% · disc. 8.2% · term. 3.0%

A DCF starts from trailing free cash flow, so it can overstate value if the last 12 months were unusually strong (or weak). Use the bear case or edit the starting cash flow if so.

Reverse DCFfor context, not a signal
Today's price assumes free cash flow grows about 2% a year for 10 years.
Implied
+2%/yr
FCF, last 3 yrs
n/a
FCF, last 5 yrs
n/a
Revenue, last 3 yrs
n/a
Revenue, last 5 yrs
n/a
Same inputs as the DCF above: trailing free cash flow 0.1B, 9.2% discount rate, 2.5% growth after year 10, net cash and today's share count. Actual growth rates are compound annual rates from SEC annual filings through FY2025; "n/a" means too little history or a negative starting year.
Edit assumptions · recalculates instantly
Your value per share–

Free cash flow = operating cash flow − capital spending, trailing 12 months (TTM to 2026-06-30). Growth default: average of 3-year revenue CAGR and latest revenue growth, capped at 30%. Years 6–10 fade linearly to terminal growth. Discount rate = 4.25% risk-free assumption + beta 1.00 (n/a) × 5% equity premium, kept within 7–13%. Bear: lower growth, +1 pt discount, 2% terminal. Bull: higher growth, −1 pt, 3%.

Multiples vs sector

Forward EPS $-1.94 vs trailing $-0.54. Forward P/E uses analysts' next-12-month estimate.

Quality & financial health

Gross margin
–
Operating margin
-44.0%
FCF margin
106.3%
Net margin
-24.5%
Return on equity
-6.3%
Return on invested capital
-238.9%
Net debt / EBITDA
–
Current ratio
5.0×
Interest cover
–
Cash conversion (OCF/NI)
–
Piotroski F-score 5/9 · last two fiscal years
✗ Positive net income✓ Positive operating cash flow✓ Return on assets improved✓ Cash flow above net income✓ Long-term debt / assets fell✗ Current ratio improved✗ No share dilution✗ Gross margin improved✓ Asset turnover improved

Altman Z-score 6.5 (safe zone; above 3.0 = safe, below 1.8 = distress). Not meaningful for banks and insurers.

Analysts

Mean target
$54
+33%
Analysts
9
None
Range
$48–$62
low – high
● price · ◆ mean target

Annual history

FYRevenueNet incomeFree cash flow
2025$46.0M$-48.9M$109.7M
2024$1.1M$-71.8M$-69.6M
2023$151.0K$4.2M$-41.6M

From the company's 10-K filings via SEC XBRL. 3-year revenue CAGR –.

Earnings

Next report: 2026-11-09 · during market · EPS est -0.40
24-1125-0325-0525-0825-1126-0326-0526-08-8.400.93
EstimateActual (beat)Actual (miss)
ReportEPS estActualSurprise
2026-08-10-0.49-0.29+41.2%
2026-05-11-0.44-0.19+56.9%
2026-03-09-0.22-0.24-8.5%
2025-11-100.79-0.10-112.3%
2025-08-110.93-0.56-160.4%
2025-05-15-0.38-0.49-29.9%
2025-03-27-0.42-0.64-52.4%
2024-11-20-0.94-8.40-793.6%
Insider trades
Bhatt Elizabeth
President and COO · 2026-10-15
Sell
$109.3K
Bhatt Elizabeth
President and COO · 2026-10-15
Sell
$40.3K
Long Daniel D.
SVP, Drug Discovery · 2026-09-01
Sell
$126.1K
Ra Capital Management, L.P.
Director, 10% owner · 2026-08-12
Sell
$31.7M
Ra Capital Management, L.P.
Director, 10% owner · 2026-08-12
Sell
$31.7M
Third Rock Ventures V, L.P.
10% owner · 2026-08-12
Sell
$7.2K
Third Rock Ventures V, L.P.
10% owner · 2026-08-12
Sell
$7.4M
Bhatt Elizabeth
President and COO · 2026-08-11
Sell
$1.1M
Long Daniel D.
SVP, Drug Discovery · 2026-08-03
Sell
$80.9K
Long Daniel D.
SVP, Drug Discovery · 2026-08-03
Sell
$34.0K
None
None · None
Sell
–

Stats refreshed 2026-10-21 18:16:19 ET from Yahoo Finance (yfinance). "–" means the data isn't available. Refresh now

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Independent research · Not investment advice · Important disclosures · Contact desk@coteau.app

Coteau Systematic Strategies publishes stock research and model portfolios. Results are hypothetical unless marked Live. Data: Yahoo Finance (15-min delayed), SEC EDGAR and the House Clerk.

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Beta 0.9 · Oct 21, 2026