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VRTX

VRTX

Vertex Pharmaceuticals
$524.52
+1.92% Oct 21 close
Health CareS&P 500 Compare
-5%+4%+14%+24%+33%Oct 2025Oct 2026Apr 2026
VRTXSPY
1W
+5.2%
1M
+2.7%
3M
+11.0%
6M
+19.8%
YTD
+15.7%
1Y
+23.0%

Live chart

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What they do

Vertex Pharmaceuticals Incorporated operates as a biotechnology company in the United States, Europe, and internationally. The company offers transformative medicines for people with serious diseases with a focus on specialty markets, such as cystic fibrosis (CF), sickle cell disease (SCD), transfusion dependent beta thalassemia (TDT), and acute pain.

Healthcare · Biotechnology

For information only · Important disclosures

Grades vs sector

Momentum
55th percentile in sector
C+
12-1 return: +22.8%
Percentile within its GICS sector across the S&P 1500.
Growth
67th percentile in sector
B
Revenue growth (YoY): +12.5%
Percentile within its GICS sector across the S&P 1500.
Value
25th percentile in sector
D+
Forward E/P: 4.0% · EBITDA/EV: 4.2%
Percentile within its GICS sector across the S&P 1500.
Profitability
88th percentile in sector
A-
Profit margin: +35.0% · Return on equity: +23.5%
Percentile within its GICS sector across the S&P 1500.
Revisions
Not enough data yet
–
EPS estimate change, 30 days (current FY): –
30-day change in analysts' current-year EPS estimate; graded across covered stocks.

Our models

Not held by any of our 5 live models right now.

Quality Growth
Outside this model's universe or screens
Momentum Top 15
ranked 99 of 499 · 12-month momentum 39.0%
Momentum Blend
Not in the current book
New Highs Growth
ranked 44 of 589 · 12-month momentum 37.7%
Coteau Long Book
Not in the current book

News

More news
Capital Group Growth (CGGR) Buys $18.3 Million More Amazon on Oct. 19
GuruFocus.com · 14h ago
Why Should You Think About Vertex Differently Now?
Trefis · Oct 20
AbbVie vs. Vertex Pharmaceuticals: Which Healthcare Stock Is a Better Buy in 2026?
Nasdaq · Oct 20
Vertex Pharmaceuticals (VRTX) files 8-K: executive or board change
SEC 8-K · Oct 20
Vertex Pharmaceuticals (VRTX) Sees $11.6 Million in Net ETF Buying on Thursday
GuruFocus.com · Oct 19

Key stats

52-week range$409.47 – $557.96
Valuation and fundamentals

Valuation & fundamentals

Bottom line
Leans expensive
Model read-out from the numbers below, not advice. Score -2 (DCF counts double).
▼DCF (base case)below the price by 27%
•Piotroski F-score6/9
▲Net debt / EBITDA-1.5x

Discounted cash flow

Bear
$253
-52%
growth 5% · disc. 10.2% · term. 2.0%
Base
$383
-27%
growth 10% · disc. 9.2% · term. 2.5%
Bull
$562
+7%
growth 13% · disc. 8.2% · term. 3.0%

A DCF starts from trailing free cash flow, so it can overstate value if the last 12 months were unusually strong (or weak). Use the bear case or edit the starting cash flow if so.

Reverse DCFfor context, not a signal
Not enough data to run a reverse DCF.
Edit assumptions · recalculates instantly
Your value per share–

Free cash flow = operating cash flow − capital spending, trailing 12 months (TTM to 2026-06-30). Growth default: average of 3-year revenue CAGR and latest revenue growth, capped at 30%. Years 6–10 fade linearly to terminal growth. Discount rate = 4.25% risk-free assumption + beta 1.00 (n/a) × 5% equity premium, kept within 7–13%. Bear: lower growth, +1 pt discount, 2% terminal. Bull: higher growth, −1 pt, 3%.

Multiples vs Health Care

P/E (trailing)
sector median 29.9×
–
Forward P/E
sector median 17.6×
–
EV / EBITDA
sector median 15.8×
–
Price / sales
sector median 3.1×
–
Price / book
sector median 3.5×
–
FCF yield
sector median 4.1%
–

Quality & financial health

Gross margin
86.0%
Operating margin
38.0%
FCF margin
30.2%
Net margin
35.0%
Return on equity
21.8%
Return on invested capital
31.9%
Net debt / EBITDA
-1.5×
Current ratio
3.2×
Interest cover
359.2×
Cash conversion (OCF/NI)
1.0×
Piotroski F-score 6/9 · last two fiscal years
✓ Positive net income✓ Positive operating cash flow✓ Return on assets improved✗ Cash flow above net income✓ Long-term debt / assets fell✓ Current ratio improved✓ No share dilution✗ Gross margin improved✗ Asset turnover improved

Analysts

No analyst targets available.

Annual history

FYRevenueNet incomeFree cash flow
2025$12.0B$4.0B$3.2B
2024$11.0B$-535.6M$-790.3M
2023$9.9B$3.6B$3.3B
2022$8.9B$3.3B$3.9B
2021$7.6B$2.3B$2.4B
2020$6.2B$2.7B$3.0B

From the company's 10-K filings via SEC XBRL. 3-year revenue CAGR +10.4%.

Earnings

Next report: –
No EPS history available.
Insider trades
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Stats refreshed – ET from Yahoo Finance (yfinance). "–" means the data isn't available. Refresh now

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coteau

Independent research · Not investment advice · Important disclosures · Contact desk@coteau.app

Coteau Systematic Strategies publishes stock research and model portfolios. Results are hypothetical unless marked Live. Data: Yahoo Finance (15-min delayed), SEC EDGAR and the House Clerk.

Beta 0.9 · Oct 21, 2026